Curation for Longevity 🧬🛍 7 - The ABC of NAD+, Nuchido, Jinfiniti, Longevity Club.
Hello 👋 and welcome to Curation for Longevity by Laura Minquini. I am the founder of MYKIGAI - a new type of community to experience longevity.
In this newsletter, I look into what could help make longevity the next big DTC (Direct To Consumer) category. 🚀
AB Testing
Anyone in startup land will tell you that AB testing is the best way to find out what your user is looking for. (A/B tests consist of a randomized experiment with two variants, A and B).
Today we are going to AB test a different format to feature NAD+.
Our Geoscientist feature NAD+
Interview with Nichola Conlon of Nuchido+ (Our Longevity Drop #3 🧬💧)
How to test your NAD+ With Jinfiniti Video (Longevity Drop #4 🧬💧)
Announcements - Longevity Club + Events
Please let us know what you thought of this format!
THE ABC OF NAD+ from our Geoscientist 👨🏽🔬
NAD is the most boring molecule in the body. This is because it is involved in nearly every aspect of cellular health. Without NAD we would be dead within seconds. Our cells produce NAD by piecing together precursor molecules (NMN, NR, nicotinamide) like a puzzle. When NAD is utilized/consumed, it is broken down into its individual constituents and must be pieced back together (recycled) via specific pathways (i.e. salvage pathway). Decline in NAD can be due to insufficient precursors (not enough puzzle pieces), increased consumption of NAD (i.e. through chronic inflammation), or insufficiency in recycling NAD once it has been utilized
1) NAD is an essential molecule (naturally produced in the body) that is required for mitochondrial health, energy production, regeneration and repair of cells, and the activation of multiple longevity pathways.
2) Levels of NAD within our blood and cells decline with age due to multiple physiological changes that occur with aging. This includes:
a) increased consumption of NAD to repair damaged DNA
b) chronic inflammation
c) decline in pathways critical for recycling NAD (after it has been used and broken down) to maintain intracellular pools (amount of NAD within cells)
d) Decline in physical movement, sleep, absorption of nutrients from diet, and mental health which are required from adequate NAD production
3) Supplementing with NAD precursors or engaging with compounds and lifestyle habits (i.e. fasting, resistance training) that support the functionality of pathways responsible for maintaining “youthful levels” of NAD within our blood and cells has been shown to significantly reduce the risk of all-cause mortality (heart disease, cancer, autoimmune disorders, and neurodegeneration)
4) NAD levels within the body/cells have been shown to be significantly influenced by lifestyle habit change and supplementation. This is where viable methods for measuring NAD levels within the blood and cells are absolutely critical in order to figure out what interventions are most effective for our personalized physiology. As we age, we may need to lean heavily on supplementation because our innate abilities to maintain NAD levels begin to decline.
5) Boosting levels of NAD within the blood and cells has been shown to reverse the process of aging (i.e. rejuvenate reproductive health post-menopause), progression of chronic diseases (i.e. reverse effects or cardiovascular disease), and significantly improve both lifespan and healthspan in preclinical studies.
Some of my favorite papers on NAD+
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795269/
https://www.sciencedirect.com/science/article/pii/S2468501118300063
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795269/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342515/
- Girish Harinath, Geoscientist at MYKIGAI.
SPECIAL ANNOUNCEMENT 📣 : A lot of our subscribers requested if we can expand the availability to our Geoscientist. We are launching the Gero-Hour service! Link Drop soon on the private channel for those who want to book a personalized hour or email Girish Harinath at geroscientist@mykigai.com to find out more.
Longevity Drop #3🧬💧 Interview with Dr. Nichola Conlon of NUCHIDO
1) In your research and experience, what is the most common cause for the decreasing NAD levels that accompany the aging process (i.e. not enough precursors, dysregulated pathways, chronic inflammation, etc)?
Research has shown that our NAD+ levels decline by around 50% every 20 years. NAD+ levels decline due to decreased ability of the cell to make and recycle NAD+ combined with increased demand for NAD+ by repair processes and inflammation.
NAD+ production declines with age
The cell manufactures its own NAD+ from precursors, and also by recycling the NAD+ it uses. This recycling process is called the salvage pathway. The salvage pathway is important because it is the primary way in which youthful cells make their own NAD+ and it’s the part of the system that breaks down as we age. That’s because the enzyme it relies on (NAMPT) declines as we get older.
NAD+ consumption increases with age
In addition to the decreased production of NAD+ there is also an increased demand for NAD+ within the cell. NAD+ is used by many different proteins within the cell and some of these proteins are known to increase with age and therefore consume more NAD+. Two of the major NAD+ consumers are PARP enzymes (repair DNA damage) and CD38 (an inflammatory protein).
PARP enzymes are involved in maintaining healthy DNA so ensuring they get enough NAD+ is vital. CD38 has been well studied and is now understood to be the largest NAD+ consumer in mammalian cells, CD38 levels increase greatly in older cells meaning it wastes a huge amount of the already limited NAD+.
Collectively, this increased demand and decreased supply leave the various cellular pathways fighting over a dwindling supply of NAD+ right at the time when they could do with more NAD+.
2) Please describe what makes your product “stand out” from other supplements that focus on boosting NAD levels within the body.
Here at Nuchido we take a different approach to boosting NAD+ levels. We appreciate that NAD+ decline is complex and cannot be fixed by simply giving the cell more precursor materials. Nuchido TIME+ utilises systems pharmacology research which determined the precise parts of the NAD+ production network that have the biggest and most sustainable impact on boosting NAD+.
The Nuchido TIME+ supplement is the result of this research, providing the cell with a combination of ingredients that are designed to:
• Boosts levels of the NAMPT enzyme to enhance the activity of the salvage pathway, enabling NAM to be recycled back into fresh NAD+
• Inhibits inflammatory proteins (CD38) which use up and waste lots of NAD+
• Inhibits NNMT and NAM methylation to prevent removal of NAD+ precursors from the cell and promotes their recycling back into fresh NAD+
By going beyond simple precursor ingredients, Nuchido TIME+ fundamentally supports the way in which youthful cells make NAD+. Our study demonstrated that our breakthrough “Whole-System” approach increased NAD+ levels by 242% on average amongst participants. View our study here.
3) Can it be beneficial for one to supplement with NuchidoTime+ before levels start declining below the “healthy range” and they start experiencing deleterious effects? Is there an optimal age you would recommend starting to take a NAD booster?
Prevention is always much easier than repairing damage and the same thought applies to NAD+ levels. Maintaining NAD+ levels as we age is easier than allowing them to drop significantly and then working to boost them.
As we age our NAD+ levels drop by approximately 50% every 20 years. This means that by the time we reach our 40's, the effects of reduced cellular function are starting to be felt. With declining levels of NAD+, cells cannot function like they used to. They cannot produce the right levels of energy or maintain critical cellular processes.
NAD+ levels are not just impacted by age but also lifestyle stressors such as smoking, drinking, exercise and sleep. Taking an NAD+ booster such as Nuchido TIME+ is a long-term investment in your cellular health and we have customers of all age groups who report feeling benefits. Our upcoming clinical trial also contains participants aged between 20 and 80 to further investigate this.
4) Based on your experience/research, what are some of the most common and consistent benefits of supplementation with Nuchido Time+?
It is no coincidence that we have our highest levels of NAD+ when we are young and that is generally when we feel our best. NAD+ is involved in over 500 chemical reactions in our cells and lots of research has been conducted into the benefits of having high cellular NAD+ levels as we age. These studies have shown that high NAD+ levels:
• Improved cellular energy levels
• Support muscle function and repair
• Improved cardiovascular function
• Support repair of damaged DNA
• Improved cognitive function
• Increase insulin sensitivity
Anecdotal feedback we receive from some of our customers is increased energy levels, improved sleep, greater mental clarity, stronger skin, and nails. There is continued research into the benefits of boosting NAD+ levels. Many scientists believing that maintaining high NAD+ levels as you age is one of the most promising ways to combat the aging process.
Not a member at MYKIGAI yet? You can purchase our subscription and NUCHIDO offer 👉🏼 HERE. (Please note this offer has ended)
Longevity Drop 🧬💧#4 Testing your NAD+ Levels
NAD+ has become extremely popular with health and longevity enthusiasts. There is one company, in particular, dominating the space with its amazing marketing and branding. You probably already know it - and if you don’t trust me you will know when you go to google and see them ranking first - so no need to go into more details.
One of the biggest proponents for NAD boosters is Dr. David Sinclair.
You can do nasal sprays!
You can do a NAD+ infusion/protocol with a licensed practitioner!
You can take supplements!
We went from nada to NAD+. 📈
But aside from feeling different how do you measure impact on your cellular health??? Only one test in the market can tell you this. Enter Jinfiniti’s Intracellualar NAD+ Test.
Jinfiniti's intracellular NAD test is an absolute "game-changer" for consumers seeking to improve their NAD levels with supplements. Prior to Jinfiniti's test, there was no reliable way for individuals to know if their NAD supplement was actually working. By working, I mean effectively raising the levels of NAD in the blood and (more importantly) within cells.
Further, different NAD supplements have varying levels of efficacy depending on an individual's genetic background, lifestyle habits, and personalized physiology. Jinfiniti's intracellular NAD test helps address all these issues with one powerful assay. This in turn will help you to truly optimize your NAD supplementation regimen and transform its potential for improving your healthspan.
To learn more you can watch the replay of our interview with the incredibly friendly Dr. Jin-Xian She, founder and CEO of Jinfiniti Precision Medicine.
Not a member at MYKIGAI yet? You can purchase our subscription and Jinfiniti’s offer 👉🏼 HERE
Announcements 📣
Coming Soon
Once upon a time, in another one of my past lives, I helped bring together the social capital and sponsors for curated events for UHNI…
Investing experts tell you that one of the most powerful strategies for accumulating wealth is compounding. So I thought why not use my compounded experience as a connector and organizer - alas finally something you can only have with time and experience - and take the Longevity as a Lifestyle concept up one notch with pop-ups and activations around the globe.
There’s no playbook that can be put on Twitter to teach you how to be a host and have people walking away with a feeling of having experienced something different.
I think the summits and events where we speak to the converted are amazing to keep up with the science but for longevity to become something people want we need to help them connect the dots in other ways. I am going for experiential here.
To join or become a partner. You can apply here 👉🏼 Longevity Club
Coming up 🗓
👉🏼 Today, learn about the novel test to get your Vaginal Microbiome with JunoBio Longevity Drop #5 🧬💧
Wednesday, November 3rd at 10 am PST / 1 pm ET @Clubhouse
👉🏼 Next Week, learn more about Fintech and Longevity and the female gender gap in accumulating wealth with one of our advisors Dr. Ira Sobel, a well-known expert in the field.
SAVE THE DATE Wednesday, November 3rd, 10 am PST / 1 pm ET @Clubhouse
Share the potential! #longevitylifestyle